| First Author | Ohtsuka S | Year | 2002 |
| Journal | Mol Cell Biol | Volume | 22 |
| Issue | 9 | Pages | 3066-77 |
| PubMed ID | 11940664 | Mgi Jnum | J:78931 |
| Mgi Id | MGI:2386494 | Doi | 10.1128/MCB.22.9.3066-3077.2002 |
| Citation | Ohtsuka S, et al. (2002) SH2-B is required for both male and female reproduction. Mol Cell Biol 22(9):3066-77 |
| abstractText | Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been shown to interact with insulin and IGF-I receptors, although the role of SH2-B in these signals has not been clarified. To investigate the role of SH2-B, we generated mice with a targeted disruption of the SH2-B gene. Both male and female SH2-B(-/-) mice showed slight retardation in growth and impaired fertility. Female knockout mice possess small, anovulatory ovaries with reduced numbers of follicles and male SH2-B(-/-) mice have small testes with a reduced number of sperm. SH2-B(-/-) cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-I-mediated reproductive pathway in mice. |
