| First Author | DeVoss JJ | Year | 2010 |
| Journal | J Immunol | Volume | 184 |
| Issue | 8 | Pages | 4236-46 |
| PubMed ID | 20237294 | Mgi Jnum | J:159869 |
| Mgi Id | MGI:4452571 | Doi | 10.4049/jimmunol.0902434 |
| Citation | DeVoss JJ, et al. (2010) An autoimmune response to odorant binding protein 1a is associated with dry eye in the aire-deficient mouse. J Immunol 184(8):4236-46 |
| abstractText | Sjogren's Syndrome (SS) is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. In this study, we show that the Aire-deficient mouse represents a new tool to investigate autoimmune dacryoadenitis and keratoconjunctivitis sicca, features of SS. Previous work in the Aire-deficient mouse suggested a role for alpha-fodrin, a ubiquitous Ag, in the disease process. Using an unbiased biochemical approach, however, we have identified a novel lacrimal gland autoantigen, odorant binding protein 1a, targeted by the autoimmune response. This novel autoantigen is expressed in the thymus in an Aire-dependent manner. The results from our study suggest that defects in central tolerance may contribute to SS and provide a new and clinically relevant model to investigate the pathogenic mechanisms in lacrimal gland autoimmunity and associated ocular surface sequelae. |
