| First Author | Iwamoto T | Year | 2004 |
| Journal | FEBS Lett | Volume | 564 |
| Issue | 1-2 | Pages | 153-6 |
| PubMed ID | 15094058 | Mgi Jnum | J:119255 |
| Mgi Id | MGI:3701588 | Doi | 10.1016/S0014-5793(04)00333-3 |
| Citation | Iwamoto T, et al. (2004) Disruption of type 5 adenylyl cyclase negates the developmental increase in Galphaolf expression in the striatum. FEBS Lett 564(1-2):153-6 |
| abstractText | The two stimulatory G protein alpha subunits, Galphas and Galphaolf, activate adenylyl cyclase in a similar way. We examined whether type 5 adenylyl cyclase knockout, the major striatal isoform, can differentially and/or developmentally change the expression of these G proteins in the striatum. Galphas and Galphaolf expressions at birth were unaffected in knockouts, which, however, demonstrated a blunted developmental increase in Galphaolf, but not Galphas. Adenylyl cyclase activity was unaffected at birth, but subsequently became lower in knockouts. These findings suggest that type 5 adenylyl cyclase does not contribute to striatal cAMP signaling at birth. However, it may play an important role in developmental changes in the expression of Galphaolf, but not Galphas. |
