| First Author | Goel AJ | Year | 2017 |
| Journal | Cell Rep | Volume | 21 |
| Issue | 8 | Pages | 2236-2250 |
| PubMed ID | 29166613 | Mgi Jnum | J:254845 |
| Mgi Id | MGI:6104089 | Doi | 10.1016/j.celrep.2017.10.102 |
| Citation | Goel AJ, et al. (2017) Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells. Cell Rep 21(8):2236-2250 |
| abstractText | Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and impaired regeneration. Here, we identify cadherin-mediated adhesion and signaling between muscle stem cells (satellite cells [SCs]) and their myofiber niche as a mechanism that orchestrates the quiescence-to-activation transition. Conditional removal of N-cadherin and M-cadherin in mice leads to a break in SC quiescence, with long-term expansion of a regeneration-proficient SC pool. These SCs have an incomplete disruption of the myofiber-SC adhesive junction and maintain niche residence and cell polarity, yet show properties of SCs in a state of transition from quiescence toward full activation. Among these is nuclear localization of beta-catenin, which is necessary for this phenotype. Injury-induced perturbation of niche adhesive junctions is therefore a likely first step in the quiescence-to-activation transition. |
