| Primary Identifier | MGI:2663097 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(Mpz-cre/ERT2)2Ueli |
| Strain of Origin | (C57BL/6 x DBA/2)F1 | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | 1.1 kb of rat Mpz promoter sequences control the expression of 350 bp from the 5' untranslated region of the human GJB1 gene and a cre-ESR1 cassette in Schwann cells. The GJB1 region includes exon 1, intron 1, and exon 2. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780. |
