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Allele : Tg(Mpz-cre/ERT2)2Ueli transgene insertion 2, Ueli Suter
Primary Identifier  MGI:2663097 Allele Type  Transgenic
Attribute String  Inducible, Recombinase Gene  Tg(Mpz-cre/ERT2)2Ueli
Strain of Origin  (C57BL/6 x DBA/2)F1 Induced With  tamoxifen
Is Recombinase  true Is Wild Type  false
molecularNote  1.1 kb of rat Mpz promoter sequences control the expression of 350 bp from the 5' untranslated region of the human GJB1 gene and a cre-ESR1 cassette in Schwann cells. The GJB1 region includes exon 1, intron 1, and exon 2. The human ESR1 sequence is mutated at G400V, M543A, and L540A in the ligand-binding domain to allow activation by 4-hydroxytamoxifen (OHT) and ICI 182,780.
  • mutations:
  • Insertion
  • synonyms:
  • P0Cx-CreERT2,
  • Tg(Mpz-cre/ESR1)2Ueli,
  • P0-CreER<T2>,
  • Tg(Mpz-cre/ESR1)2Ueli,
  • P0-CreER<T2>,
  • P0Cx-CreERT2
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

Trail: Allele

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Trail: Allele




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