| First Author | Groves MG | Year | 1980 |
| Journal | J Immunol | Volume | 125 |
| Issue | 3 | Pages | 1395-9 |
| PubMed ID | 6774020 | Mgi Jnum | J:6374 |
| Mgi Id | MGI:54850 | Doi | 10.4049/jimmunol.125.3.1395 |
| Citation | Groves MG, et al. (1980) Host defenses in experimental scrub typhus: mapping the gene that controls natural resistance in mice. J Immunol 125(3):1395-9 |
| abstractText | Natural resistance of mice to lethal ifections of Rickettsia tsutsugamushi, strain Gilliam, is controlled by a single, autosomal, dominant gene, which we have designated Ric, with r and s representing the resistant nd susceptible alleles, respectively. Using three sets of recombinant inbred mouse strains (BXD, BXH, and BXJ), the Ric locus was mapped to Chromosome 5 closely linked to the retinal degeneration (rd) locus. This linkage was confirmed by a backcross analysis. Based on the RI strains and the C57BL/6Ty-le congenic strain (the only proven Ric-rd cross-over), we estimate the recombination frequency between Ric and rd to be 0.015. Three presumptive Ric-rd recombinants detected among 93 backcross mice may represent caes of incomplete penetrance of the resistance allele rather than recombination. Analyis of th C57BL/6JTy-le congenic strain indicates that Ric is proximal to rd on Chromosome 5. If so, the correct gene order is Pgm-1-W-Ric-rd-Gus. |
