| First Author | Marques S | Year | 2018 |
| Journal | Dev Cell | Volume | 46 |
| Issue | 4 | Pages | 504-517.e7 |
| PubMed ID | 30078729 | Mgi Jnum | J:272557 |
| Mgi Id | MGI:6284048 | Doi | 10.1016/j.devcel.2018.07.005 |
| Citation | Marques S, et al. (2018) Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development. Dev Cell 46(4):504-517.e7 |
| abstractText | Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions. |
