| Primary Identifier | MGI:2663944 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(NES-TVA)J12Ech |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| description | Glial progenitor cells in transgenic mice are specifically susceptible to infection by viral vectors. |
| molecularNote | The transgene expresses TVA, the receptor for avian retrovirus ALV, subgroup A (ALV-A), from a quail cDNA under control of a modified human nestin promoter that includes the second-intron enhancer - which in adult mice directs expression specifically in early glial progenitor cells - and the herpes simplex virus thymidine kinase (HSV-TK) promoter. Cells presenting this receptor can be infected by replication-competent ALV splice acceptor (RCAS) vectors, permitting cell type specific expression of vector-borne genes. |
