| Primary Identifier | MGI:2664380 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Cd28 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of a 0.5 kb region containing most of exon 2 with a neomycin resistance cassette. Exon 2 encodes the Ig-like region, an alternative splice site, a putative ligand-binding domain, and represents more than 70% of the extracellular domain. Absence of gene expression was verified by flow cytometry of CD4+ T cells from homozygous mutant animals. |
