| First Author | Izon DJ | Year | 2001 |
| Journal | Immunity | Volume | 14 |
| Issue | 3 | Pages | 253-64 |
| PubMed ID | 11290335 | Mgi Jnum | J:68348 |
| Mgi Id | MGI:1932593 | Doi | 10.1016/s1074-7613(01)00107-8 |
| Citation | Izon DJ, et al. (2001) Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity 14(3):253-64 |
| abstractText | Notch signaling regulates cell fate decisions in multiple lineages. We demonstrate in this report that retroviral expression of activated Notch1 in mouse thymocytes abrogates differentiation of immature CD4+CD8+ thymocytes into both CD4 and CD8 mature single-positive T cells. The ability of Notch1 to inhibit T cell development was observed in vitro and in vivo with both normal and TCR transgenic thymocytes. Notch1-mediated developmental arrest was dose dependent and was associated with impaired thymocyte responses to TCR stimulation. Notch1 also inhibited TCR-mediated signaling in Jurkat T cells. These data indicate that constitutively active Notch1 abrogates CD4+ and CD8+ maturation by interfering with TCR signal strength and provide an explanation for the physiological regulation of Notch expression during thymocyte development. |
