| First Author | Wu JN | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 11 | Pages | 6681-9 |
| PubMed ID | 16709827 | Mgi Jnum | J:131800 |
| Mgi Id | MGI:3774484 | Doi | 10.4049/jimmunol.176.11.6681 |
| Citation | Wu JN, et al. (2006) Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection. J Immunol 176(11):6681-9 |
| abstractText | Adhesion- and degranulation-promoting adapter protein (ADAP) is required in TCR-induced activation and proliferation of peripheral T cells. Loss of ADAP also impairs TCR-initiated inside-out activation of the integrin LFA-1 (CD11a/CD18, alphaLbeta2). In this study, we demonstrate that ADAP-deficient CD4/CD8 double-positive (DP) cells have a diminished ability to proliferate, and that these DP thymocytes up-regulate CD69 poorly in vivo. Moreover, in both MHC class I- and class II-restricted TCR transgenic models, loss of ADAP interferes with both positive and negative selection. ADAP deficiency also impairs the ability of transgene-bearing DP thymocytes to form conjugates with Ag-loaded presenting cells. These findings suggest that ADAP is critical for thymocyte development and selection. |
