| First Author | Bach EA | Year | 1995 |
| Journal | Science | Volume | 270 |
| Issue | 5239 | Pages | 1215-8 |
| PubMed ID | 7502050 | Mgi Jnum | J:331606 |
| Mgi Id | MGI:7388690 | Doi | 10.1126/science.270.5239.1215 |
| Citation | Bach EA, et al. (1995) Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets. Science 270(5239):1215-8 |
| abstractText | Interferon gamma (IFN-gamma) responsiveness in certain cells depends on the state of cellular differentiation or activation. Here an in vitro developmental system was used to show that IFN-gamma produced during generation of the CD4+ T helper cell type 1 (TH1) subset extinguishes expression of the IFN-gamma receptor beta subunit, resulting in TH1 cells that are unresponsive to IFN-gamma. This beta chain loss also occurred in IFN-gamma-treated TH2 cells and thus represents a specific response of CD4+ T cells to IFN-gamma rather than a TH1-specific differentiation event. These results define a mechanism of cellular desensitization where a cytokine down-regulates expression of a receptor subunit required primarily for signaling and not ligand binding. |
