| First Author | Beura LK | Year | 2019 |
| Journal | J Exp Med | Volume | 216 |
| Issue | 5 | Pages | 1214-1229 |
| PubMed ID | 30923043 | Mgi Jnum | J:275404 |
| Mgi Id | MGI:6306027 | Doi | 10.1084/jem.20181365 |
| Citation | Beura LK, et al. (2019) CD4(+) resident memory T cells dominate immunosurveillance and orchestrate local recall responses. J Exp Med 216(5):1214-1229 |
| abstractText | This study examines the extent to which memory CD4(+) T cells share immunosurveillance strategies with CD8(+) resident memory T cells (TRM). After acute viral infection, memory CD4(+) T cells predominantly used residence to survey nonlymphoid tissues, albeit not as stringently as observed for CD8(+) T cells. In contrast, memory CD4(+) T cells were more likely to be resident within lymphoid organs than CD8(+) T cells. Migration properties of memory-phenotype CD4(+) T cells in non-SPF parabionts were similar, generalizing these results to diverse infections and conditions. CD4(+) and CD8(+) TRM shared overlapping transcriptional signatures and location-specific features, such as granzyme B expression in the small intestine, revealing tissue-specific and migration property-specific, in addition to lineage-specific, differentiation programs. Functionally, mucosal CD4(+) TRM reactivation locally triggered both chemokine expression and broad immune cell activation. Thus, residence provides a dominant mechanism for regionalizing CD4(+) T cell immunity, and location enforces shared transcriptional, phenotypic, and functional properties with CD8(+) T cells. |
