| First Author | Hobbs SJ | Year | 2019 |
| Journal | Cell Rep | Volume | 29 |
| Issue | 10 | Pages | 2990-2997.e2 |
| PubMed ID | 31801067 | Mgi Jnum | J:301222 |
| Mgi Id | MGI:6489130 | Doi | 10.1016/j.celrep.2019.10.126 |
| Citation | Hobbs SJ, et al. (2019) Targeted Expansion of Tissue-Resident CD8(+) T Cells to Boost Cellular Immunity in the Skin. Cell Rep 29(10):2990-2997.e2 |
| abstractText | Tissue-resident memory (TRM) CD8(+) T cells are positioned within environmental barrier tissues to provide a first line of defense against pathogen entry, but whether these specialized T cell populations can be readily boosted to increase protective immunity is ill defined. Here, we demonstrate that repeated activation of rare, endogenous TRM CD8(+) T cells, using only topical application of antigenic peptide causes delayed-type hypersensitivity and increases the number of antigen-specific TRM CD8(+) T cells, specifically in the challenged skin by approximately 15-fold. Expanded TRM CD8(+) T cells in the skin are derived from memory T cells recruited out of the circulation that became CD69(+) tissue residents following a local antigen encounter. Notably, recruited circulating memory CD8(+) T cells of a different antigen specificity could be coerced to become tissue resident using a dual-peptide challenge strategy. Expanded TRM CD8(+) T cells significantly increase anti-viral protection, suggesting that this approach could be used to rapidly boost tissue-specific cellular immunity. |
