| First Author | Leiss V | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 452 |
| Issue | 1 | Pages | 151-6 |
| PubMed ID | 25152402 | Mgi Jnum | J:220101 |
| Mgi Id | MGI:5632238 | Doi | 10.1016/j.bbrc.2014.08.071 |
| Citation | Leiss V, et al. (2014) Expression of cGMP-dependent protein kinase type I in mature white adipocytes. Biochem Biophys Res Commun 452(1):151-6 |
| abstractText | The presence of cGMP-dependent protein kinase I (cGKI) in murine adipocytes has been questioned, although cGKI was implicated in the thermogenic program of fat cells (FCs) and to exert anti-hypertrophic/-inflammatory effects in white adipose tissue. Herein, cGKI was detected in adipocytes from control mice, whereas FCs from global cGKI knockouts (cGKI(-/-)) and cGKIalpha rescue (alphaRM) mice remained cGKI-negative. cGKI mutants exhibit decreased adipocyte size, plasma leptin levels and reduced body-weights as compared to litter-matched controls. Low abundance of adiponectin in WAT and plasma of alphaRM animals together with previously confirmed high IL-6 levels indicate a low-grade inflammation. However, alphaRMs were protected from streptozotocin-induced hyperglycemia. Our results suggest that cGMP/cGKI affects both glucose and FC homeostasis in more complex mode than previously thought. |
