| First Author | Dedic N | Year | 2018 |
| Journal | Nat Neurosci | Volume | 21 |
| Issue | 6 | Pages | 803-807 |
| PubMed ID | 29786085 | Mgi Jnum | J:264526 |
| Mgi Id | MGI:6196819 | Doi | 10.1038/s41593-018-0151-z |
| Citation | Dedic N, et al. (2018) Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci 21(6):803-807 |
| abstractText | The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release. |
