Primary Identifier | MGI:2669961 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Icosl |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Most of exon 2 and all of exon 3 which together encode for the leader sequence, the first IgV domain and the ICOS-binding site were replaced with a neomycin-resistance gene. Loss of protein expression in mice homozygous for this deletion was established by flow cytometric analysis of spleen cells. |