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Allele : Icosl<tm1Mak> icos ligand; targeted mutation 1, Tak W Mak

Primary Identifier  MGI:2669961 Allele Type  Targeted
Attribute String  Null/knockout Gene  Icosl
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Most of exon 2 and all of exon 3 which together encode for the leader sequence, the first IgV domain and the ICOS-binding site were replaced with a neomycin-resistance gene. Loss of protein expression in mice homozygous for this deletion was established by flow cytometric analysis of spleen cells.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • B7RP-1 KO,
  • B7h<->,
  • B7RP-1 KO,
  • ICOSL KO,
  • B7h<->,
  • Icosl-,
  • ICOSL KO,
  • Icosl-
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

36 Publication categories

Trail: Allele