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Allele : Hoxb1<tm6(cre)Mrc> homeobox B1; targeted mutation 6, Mario R Capecchi
Primary Identifier  MGI:2668513 Allele Type  Targeted
Attribute String  Recombinase Gene  Hoxb1
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  true Is Wild Type  false
description  Cre expression under the control of the Hoxb1 promoter was used to activate reporter genes in the descendants of rhombomere 4-derived neural crest cells (r4).
  • first expressed at E7 in the caudal primitive streak in mesodermal somites and caudal tail
  • by 10-11 somite stage reporter activity is found in ectodermal cells of r4
  • by E10.5 caudal mesoderm derivatives are found throughout the embryonic trunk and limbs extending rostrally to the caudal hindbrain
  • at E11.5 cells are found in the neuroepithelium and 2nd branchial arch
  • by E14.5, cells are found throughout the embryo
    • in cartilage and bone of the neck and external ear
    • cells of the tongue, salivary gland, pterygopalatine ganglia
    • cell bodies and axon tracts of the facial nerve (VII)
    • CNS localization is primarily to the 7th and 8th sensory ganglion complex and the 7th cranial nerve
      • motor neurons of the facial nerve
      • glial cells
molecularNote  An IRES-Cre cassette containing a neomycin selection gene flanked with frt sites was introduced into the 3' untranslated region downstream of the translational stop codon and upstream of the endogenous polyadenylation signal. Crossing with a flp deleter line to excise the neomycin resistance gene resulted in animals able to express Cre from the Hoxb1 locus without interfering with endogenous Hoxb1 activity.
  • mutations:
  • Insertion
  • synonyms:
  • Hoxb1-Ires-Cre,
  • Hoxb1-Ires-Cre
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Carried By

1 Driven By

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