| First Author | Pacholczyk R | Year | 2001 |
| Journal | J Immunol | Volume | 166 |
| Issue | 4 | Pages | 2357-63 |
| PubMed ID | 11160293 | Mgi Jnum | J:126996 |
| Mgi Id | MGI:3762465 | Doi | 10.4049/jimmunol.166.4.2357 |
| Citation | Pacholczyk R, et al. (2001) An incremental increase in the complexity of peptides bound to class II MHC changes the diversity of positively selected alpha beta TCRs. J Immunol 166(4):2357-63 |
| abstractText | Positive selection of the normal repertoire of TCRs results from low-avidity interactions with a set of self-peptides bound to the MHC molecules expressed by thymic epithelial cells. The contribution of the individual peptide to positive selection remains a matter of debate. Here, for the first time, we show that two covalent class II MHC-peptide complexes positively select different TCRs expressing a common transgenic TCRbeta-chain and endogenous TCRalpha-chains. Simultaneous expression of both A(b)-peptide complexes changed the diversity of positively selected TCRs, indicating an additive and possibly synergistic effect of various peptides in this process. |
