| First Author | Munk AS | Year | 2019 |
| Journal | Cell Rep | Volume | 26 |
| Issue | 11 | Pages | 2955-2969.e3 |
| PubMed ID | 30865886 | Mgi Jnum | J:277373 |
| Mgi Id | MGI:6330929 | Doi | 10.1016/j.celrep.2019.02.050 |
| Citation | Munk AS, et al. (2019) PDGF-B Is Required for Development of the Glymphatic System. Cell Rep 26(11):2955-2969.e3 |
| abstractText | The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb(ret/ret) suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport. |
