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Allele : Ro60<tm1Woln> Ro60, Y RNA binding protein; targeted mutation 1, Sandra L Wolin

Primary Identifier	MGI:2670227	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Ro60
Transmission	Germline	Strain of Origin	129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetectable by Western blot analysis of homozygous mutant brain extracts.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Ro<-/->,
Ro<-/->

earliestPublication:
Xue D, et al. (2003) A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proc Natl Acad Sci U S A 100(13):7503-8

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

5 Publication categories

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