| First Author | Kim YI | Year | 2018 |
| Journal | J Immunol | Volume | 201 |
| Issue | 4 | Pages | 1287-1294 |
| PubMed ID | 29987162 | Mgi Jnum | J:264313 |
| Mgi Id | MGI:6195345 | Doi | 10.4049/jimmunol.1701459 |
| Citation | Kim YI, et al. (2018) CX3CR1(+) Macrophages and CD8(+) T Cells Control Intestinal IgA Production. J Immunol 201(4):1287-1294 |
| abstractText | Secretory IgA is a key host defense mechanism that controls the intestinal microbiota. We investigated the role of CD11c(+)CX3CR1(+)CD64(+) macrophages in IgA production in the intestine. Intestinal CX3CR1(+) macrophages directly induced IgA secretion by B cells. Ag delivery to lamina propria (LP) CX3CR1(+) macrophages specifically induced intestinal IgA production. The induction of IgA by CX3CR1(+) macrophages required BAFF, a proliferation-inducing ligand, and TNF-alpha, but was surprisingly independent of TLR-mediated microbial recognition and retinoic acid signaling. IgA secretion by CX3CR1(+) macrophages was enhanced by LP CD8(+) T cells through the secretion of IL-9 and IL-13. CX3CR1(+) macrophages and CD8(+) T cells induced IgA production by B cells independently of mesenteric lymph nodes and Peyer patches. Our data reveal a previously unrecognized cellular circuitry in which LP CX3CR1(+) macrophages, B cells, and CD8(+) T cells coordinate the protective Ig secretion in the small intestine upon peripheral Ag delivery. |
