| Primary Identifier | MGI:2670783 | Allele Type | Targeted |
| Attribute String | Not Specified | Gene | Fes |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A dinucleotide substitution was introduced at codon 588 (exon 14), converting the lysine codon to an arginine codon (K588R). While protein was detected at wild-type levels in homozygous mutant mice, the absence of lysine 588, a conserved residue of the kinase subdomain II, resulted in an ablation of catalytic activity. The targeting construct also included neo and tk selection genes in the 3' untranslated region. |
