| First Author | Chavan R | Year | 2017 |
| Journal | Biol Open | Volume | 6 |
| Issue | 1 | Pages | 1-7 |
| PubMed ID | 27875243 | Mgi Jnum | J:238721 |
| Mgi Id | MGI:5823512 | Doi | 10.1242/bio.021519 |
| Citation | Chavan R, et al. (2017) REV-ERBalpha regulates Fgf21 expression in the liver via hepatic nuclear factor 6. Biol Open 6(1):1-7 |
| abstractText | The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBalpha elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBalpha modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBalpha regulates metabolism and reproduction, at least in part, via regulation of Fgf21. |
