| First Author | Schnell A | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 6 | Pages | e99883 |
| PubMed ID | 24932636 | Mgi Jnum | J:218863 |
| Mgi Id | MGI:5618596 | Doi | 10.1371/journal.pone.0099883 |
| Citation | Schnell A, et al. (2014) The nuclear receptor REV-ERBalpha regulates Fabp7 and modulates adult hippocampal neurogenesis. PLoS One 9(6):e99883 |
| abstractText | The function of the nuclear receptor Rev-erbalpha (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbalpha knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERBalpha. Loss of Rev-erbalpha manifested in memory and mood related behavioral phenotypes and led to overexpression of Fabp7 in various brain areas including the subgranular zone (SGZ) of the hippocampus, where neuronal progenitor cells (NPCs) can initiate adult neurogenesis. We found increased proliferation of hippocampal neurons and loss of its diurnal pattern in Rev-erbalpha KO mice. In vitro, proliferation and migration of glioblastoma cells were affected by manipulating either Fabp7 expression or REV-ERBalpha activity. These results suggest an important role of Rev-erbalpha and Fabp7 in adult neurogenesis, which may open new avenues for treatment of gliomas as well as neurological diseases such as depression and Alzheimer. |
