| First Author | Yoo JY | Year | 2002 |
| Journal | Cell | Volume | 108 |
| Issue | 3 | Pages | 331-44 |
| PubMed ID | 11853668 | Mgi Jnum | J:77307 |
| Mgi Id | MGI:2181336 | Doi | 10.1016/s0092-8674(02)00636-0 |
| Citation | Yoo JY, et al. (2002) Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell 108(3):331-44 |
| abstractText | Alternative splicing of the gene for Stat3, a transcription factor activated by the IL-6 family of cytokines, produces two isoforms: Stat3alpha and a dominant-negative variant, Stat3beta. Stat3beta-deficient mice were generated by gene targeting. Despite intact expression and phosphorylation of Stat3alpha, overall Stat3 activity was impaired in Stat3beta(-/-) cells. Global comparison of transcription in Stat3beta(+/+) and Stat3beta(-/-) cells revealed stable differences. Stat3beta-deficient mice exhibit diminished recovery from endotoxic shock and hyperresponsiveness of a subset of endotoxin-inducible genes in liver. The hepatic response to endotoxin in wild-type mice is accompanied by a transient increase in the ratio of Stat3beta to Stat3alpha. These findings indicate a critical role for Stat3beta in the control of systemic inflammation. |
