| First Author | Fang M | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 4 | Pages | 579-89 |
| PubMed ID | 21439856 | Mgi Jnum | J:171382 |
| Mgi Id | MGI:4949811 | Doi | 10.1016/j.immuni.2011.02.015 |
| Citation | Fang M, et al. (2011) CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease. Immunity 34(4):579-89 |
| abstractText | It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK cells recognize virus-infected cells are known. Here we show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus. Ectromelia virus-infected cells expressing the major histocompatibility complex (MHC) class Ib molecule Qa-1(b) are specifically recognized by the activating receptor formed by CD94 and NKG2E. Because CD94-NKG2 receptors and their ligands are highly conserved in rodents and humans, a similar mechanism may exist during human infections with the smallpox and monkeypox viruses, which are highly homologous to ectromelia virus. |
