| First Author | Kaji K | Year | 2001 |
| Journal | J Bone Miner Res | Volume | 16 |
| Issue | 9 | Pages | 1593-9 |
| PubMed ID | 11547829 | Mgi Jnum | J:112517 |
| Mgi Id | MGI:3656441 | Doi | 10.1359/jbmr.2001.16.9.1593 |
| Citation | Kaji K, et al. (2001) Tumor necrosis factor alpha-induced osteoclastogenesis requires tumor necrosis factor receptor-associated factor 6. J Bone Miner Res 16(9):1593-9 |
| abstractText | Although tumor necrosis factor receptor-associated factor 6 (TRAF6) is required in receptor activator of NF-kappaB-receptor activator of NF-kappaB ligand (RANK-RANKL) signaling for osteoclastogenesis, it has remained unclear whether TRAF6 is crucial in tumor necrosis factor alpha (TNF-alpha)-induced osteoclastogenesis. We examined TRAF6 function in the TNF-alpha-induced osteoclastogenesis by using osteoclast progenitor cells from TRAF6-deficient mice. The results indicated that TNF-alpha did not effectively induce osteoclast differentiation from osteoclast progenitor cells derived from these mice into mature multinucleated osteoclasts, although c-jun N-terminal kinase (JNK) and TNF-alpha activation was observed in osteoclast progenitor cells. Thus, we have provided the first evidence showing that TRAF6 is involved in TNF-alpha-induced osteoclastogenesis. |
