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Allele : Mfge8<tm1Shur> milk fat globule EGF and factor V/VIII domain containing; targeted mutation 1, Barry D Shur

Primary Identifier  MGI:2675967 Allele Type  Targeted
Attribute String  Null/knockout Gene  Mfge8
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  A single loxP site remained in place of exon 1 after homologous recombination of flanking loxP sites and subsequent cre-mediated excision. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of testicular cDNA using primers spanning exons 2 and 3 and exons 7 and 8. The absence of protein was indicated by Western blot analysis and by indirect immunofluorescence of live sperm.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • SED1-null,
  • SED1-null
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

9 Publication categories