| First Author | Wollmann G | Year | 2006 |
| Journal | Vision Res | Volume | 46 |
| Issue | 5 | Pages | 688-98 |
| PubMed ID | 16289664 | Mgi Jnum | J:112816 |
| Mgi Id | MGI:3663587 | Doi | 10.1016/j.visres.2005.08.030 |
| Citation | Wollmann G, et al. (2006) Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice. Vision Res 46(5):688-98 |
| abstractText | We studied electrophysiological properties of cultured retinal pigment epithelial (RPE) cells from mouse and a mouse model for Norrie disease. Wild-type RPE cells revealed the expression of ion channels known from other species: delayed-rectifier K(+) channels composed of Kv1.3 subunits, inward rectifier K(+) channels, Ca(V)1.3 L-type Ca(2+) channels and outwardly rectifying Cl(-) channels. Expression pattern and the ion channel characteristics current density, blocker sensitivity, kinetics and voltage-dependence were compared in cells from wild-type and Norrie mice. Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models. |
