| First Author | Nakazawa H | Year | 2019 |
| Journal | Neurobiol Learn Mem | Volume | 162 |
| Pages | 47-58 | PubMed ID | 31103466 |
| Mgi Jnum | J:289608 | Mgi Id | MGI:6434581 |
| Doi | 10.1016/j.nlm.2019.04.014 | Citation | Nakazawa H, et al. (2019) Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse. Neurobiol Learn Mem 162:47-58 |
| abstractText | For social mammals, recognition of conspecifics and discrimination of each other (social memory) is crucial to living in a stable colony. Here, we investigated whether kallikrein-related peptidase 8 (KLK8)-neuregulin 1 (NRG1)-ErbB signaling is crucial for social discrimination behavior using the social discrimination three chamber behavioral test. Klk8 knockout mice (NRG1-deactivated mice) exhibited normal social approach but impaired social discrimination. Intraventricular injection of recombinant NRG1177-246 into Klk8 knockout mice reversed this impaired social discrimination. This study reveals that KLK8 is a key regulator of NRG1-ErbB signaling, which contributes to social discrimination behavior. |
