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Allele : Thra<tm1Brnt> thyroid hormone receptor alpha; targeted mutation 1, Gregory A Brent

Primary Identifier  MGI:2679056 Allele Type  Targeted
Attribute String  Dominant negative Gene  Thra
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A cytosine to adnenosine transversion point mutation was engineered in exon 9, using a "hit and run" strategey, affecting a proline to histidine missense mutation at codon 398 (P398H). The mutation is dominant-negative.
  • mutations:
  • Single point mutation
  • synonyms:
  • TRalpha P398H,
  • P398H,
  • TRalpha P398H,
  • P398H
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories