| First Author | Kitsberg D | Year | 1999 |
| Journal | J Neurosci | Volume | 19 |
| Issue | 19 | Pages | 8244-51 |
| PubMed ID | 10493725 | Mgi Jnum | J:77283 |
| Mgi Id | MGI:2181310 | Doi | 10.1523/JNEUROSCI.19-19-08244.1999 |
| Citation | Kitsberg D, et al. (1999) Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. J Neurosci 19(19):8244-51 |
| abstractText | Apoptosis is a very general phenomenon, but only a few reports concern astrocytes. Indeed, astrocytes express receptors for tumor necrosis factor (TNF) alpha, a cytokine demonstrated on many cells and tissues to mediate apoptosis after recruitment of adaptor proteins containing a death effector domain (DED). PEA-15 is a DED-containing protein prominently expressed in the CNS and particularly abundant in astrocytes. This led us to investigate if PEA-15 expression could be involved in astrocytic protection against deleterious effects of TNF. In vitro assays evidence that PEA-15 may bind to DED-containing protein FADD and caspase-8 known to be apical adaptors of the TNF apoptotic signaling. After generation of PEA-15 null mutant mice, our results demonstrate that PEA-15 expression increases astrocyte survival after exposure to TNF. |
