| First Author | Schenkel AR | Year | 2006 |
| Journal | Exp Mol Pathol | Volume | 81 |
| Issue | 1 | Pages | 23-30 |
| PubMed ID | 16457810 | Mgi Jnum | J:124851 |
| Mgi Id | MGI:3722700 | Doi | 10.1016/j.yexmp.2005.11.007 |
| Citation | Schenkel AR, et al. (2006) Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis. Exp Mol Pathol 81(1):23-30 |
| abstractText | Platelet Endothelial Cell Adhesion Molecule (PECAM) is an adhesion and signaling molecule used for leukocyte extravasation. We have generated two strains of PECAM-deficient mouse, one in the original C57BL/6 and a second by backcrossing nice generations into the FVB/n strain. The FVB/n strain has reduced responses in models of acute inflammation. We show here that this strain is also susceptible to a chronic pneumonia which leads to pulmonary fibrosis. In contrast, PECAM-deficient C57BL/6 mice do not develop this lung disease and have normal responses in acute models of inflammation. This demonstrates that PECAM-dependent and -independent mechanisms are found in both acute and chronic inflammation. Further, the PECAM-deficient FVB/n strain has many pathologic similarities to the human disease Idiopathic Pulmonary Fibrosis, suggesting that similar molecular mechanisms may play a role in human disease. |
