| First Author | Poliak S | Year | 2003 |
| Journal | J Cell Biol | Volume | 162 |
| Issue | 6 | Pages | 1149-60 |
| PubMed ID | 12963709 | Mgi Jnum | J:85502 |
| Mgi Id | MGI:2675531 | Doi | 10.1083/jcb.200305018 |
| Citation | Poliak S, et al. (2003) Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol 162(6):1149-60 |
| abstractText | In myelinated axons, K+ channels are concealed under the myelin sheath in the juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin superfamily. Deletion of Caspr2 in mice by gene targeting revealed that it is required to maintain K+ channels at this location. Furthermore, we show that the localization of Caspr2 and clustering of K+ channels at the juxtaparanodal region depends on the presence of TAG-1, an immunoglobulin-like cell adhesion molecule that binds Caspr2. These results demonstrate that Caspr2 and TAG-1 form a scaffold that is necessary to maintain K+ channels at the juxtaparanodal region, suggesting that axon-glia interactions mediated by these proteins allow myelinating glial cells to organize ion channels in the underlying axonal membrane. |
