| First Author | Oron O | Year | 2019 |
| Journal | Transl Psychiatry | Volume | 9 |
| Issue | 1 | Pages | 257 |
| PubMed ID | 31624228 | Mgi Jnum | J:294529 |
| Mgi Id | MGI:6455397 | Doi | 10.1038/s41398-019-0584-5 |
| Citation | Oron O, et al. (2019) Gene network analysis reveals a role for striatal glutamatergic receptors in dysregulated risk-assessment behavior of autism mouse models. Transl Psychiatry 9(1):257 |
| abstractText | Autism spectrum disorder (ASD) presents a wide, and often varied, behavioral phenotype. Improper assessment of risks has been reported among individuals diagnosed with ASD. Improper assessment of risks may lead to increased accidents and self-injury, also reported among individuals diagnosed with ASD. However, there is little knowledge of the molecular underpinnings of the impaired risk-assessment phenotype. In this study, we have identified impaired risk-assessment activity in multiple male ASD mouse models. By performing network-based analysis of striatal whole transcriptome data from each of these ASD models, we have identified a cluster of glutamate receptor-associated genes that correlate with the risk-assessment phenotype. Furthermore, pharmacological inhibition of striatal glutamatergic receptors was able to mimic the dysregulation in risk-assessment. Therefore, this study has identified a molecular mechanism that may underlie risk-assessment dysregulation in ASD. |
