| First Author | Mena MA | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 1 | Pages | 168-74 |
| PubMed ID | 19084014 | Mgi Jnum | J:142656 |
| Mgi Id | MGI:3821912 | Doi | 10.1016/j.febslet.2008.11.051 |
| Citation | Mena MA, et al. (2009) NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice. FEBS Lett 583(1):168-74 |
| abstractText | Parkin mutations produce Parkinson's disease (PD) in humans and nigrostriatal dopamine lesions related to increased free radicals in mice. We examined the effects of NP7, a synthetic, marine derived, free radical scavenger which enters the brain, on H(2)O(2) toxicity in cultured neurons and glia from wild-type (WT) and parkin null mice (PK-KO). NP7, 5-10muM, prevented the H(2)O(2) induced apoptosis and necrosis of midbrain neuronal and glial cultures from WT and PK-KO mice. NP7 suppressed microglial activation and the H(2)O(2) induced drop-out of dopamine neurons(.) Furthermore, NP7 prevented the increased phosphorylation of ERK and AKT induced by H(2)O(2). NP7 may be a promising neuroprotector against oxidative stress in PD. |
