|  Help  |  About  |  Contact Us

Allele : Pten<tm2.1Ppp> phosphatase and tensin homolog; targeted mutation 2.1, Pier Paolo Pandolfi
Primary Identifier  MGI:2679886 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Pten
Transmission  Germline Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase  false Is Wild Type  false
description 

Phenotypic Similarity to Human Syndrome: Follicular Thyroid Carcinoma J:236513 (DOID:3962) in double Kras and Pten conditional (Tg(Tpo-cre)1Shk) mutants.

Phenotypic Similarity to Human Syndrome: Anaplastic Thyroid Cancer J:209788 in double Trp53 and Pten homozygous conditional (Tg(TPO-cre)1Shk) mice.

molecularNote  Exons 4 and 5 were left flanked by single loxP sites after the floxed neo cassette was removed from intron 3 of Ptentm2Ppp via in vivo cre mediated recombination.
  • mutations:
  • Insertion
  • synonyms:
  • Pten<fl>,
  • Pten<lox4-5>,
  • Pten<L>,
  • Pten<fl>,
  • Pten<L>,
  • Pten<f>,
  • Pten<loxP>,
  • Pten<lx>,
  • Pten<lx>,
  • Pten<loxP>,
  • Pten<f>,
  • Pten<lox4-5>,
  • Pten<lox4-5>
Paste the following link
Quick Links:
SummaryGenomePhenotypeOther
 
Quick Links:
SummaryGenomePhenotypeOther
 
Lists
This Allele isn't in any lists. Upload a list.

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

5 Carried By

0 Driven By

186 Publication categories





MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom