| First Author | He Y | Year | 2014 |
| Journal | Nat Neurosci | Volume | 17 |
| Issue | 7 | Pages | 943-52 |
| PubMed ID | 24859199 | Mgi Jnum | J:213201 |
| Mgi Id | MGI:5583892 | Doi | 10.1038/nn.3732 |
| Citation | He Y, et al. (2014) ALK5-dependent TGF-beta signaling is a major determinant of late-stage adult neurogenesis. Nat Neurosci 17(7):943-52 |
| abstractText | The transforming growth factor-beta (TGF-beta) signaling pathway serves critical functions in CNS development, but, apart from its proposed neuroprotective actions, its physiological role in the adult brain is unclear. We observed a prominent activation of TGF-beta signaling in the adult dentate gyrus and expression of downstream Smad proteins in this neurogenic zone. Consistent with a function of TGF-beta signaling in adult neurogenesis, genetic deletion of the TGF-beta receptor ALK5 reduced the number, migration and dendritic arborization of newborn neurons. Conversely, constitutive activation of neuronal ALK5 in forebrain caused a marked increase in these aspects of neurogenesis and was associated with higher expression of c-Fos in newborn neurons and with stronger memory function. Our findings describe an unexpected role for ALK5-dependent TGF-beta signaling as a regulator of the late stages of adult hippocampal neurogenesis, which may have implications for changes in neurogenesis during aging and disease. |
