| Primary Identifier | MGI:2678400 | Allele Type | Gene trapped |
| Attribute String | Null/knockout, Reporter | Gene | Nphs1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The endogenous locus was disrupted by the random insertion of a gene trap vector containing a splice acceptor site followed by Beta-geo and a polyadenylation signal into exon 8, which encodes the third Ig-motif. Sequencing identified a nonsense mutation 14 codons downstream of the vector insertion site. Protein was undetected in homozygous mutant mice by Western blot analysis of kidney extracts. |
