| First Author | Guy CT | Year | 1992 |
| Journal | Mol Cell Biol | Volume | 12 |
| Issue | 3 | Pages | 954-61 |
| PubMed ID | 1312220 | Mgi Jnum | J:46460 |
| Mgi Id | MGI:1199237 | Doi | 10.1128/mcb.12.3.954 |
| Citation | Guy CT, et al. (1992) Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-61 |
| abstractText | The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential. |
