| First Author | Bornes L | Year | 2019 |
| Journal | Cell Rep | Volume | 29 |
| Issue | 9 | Pages | 2565-2569.e3 |
| PubMed ID | 31775027 | Mgi Jnum | J:306419 |
| Mgi Id | MGI:6715200 | Doi | 10.1016/j.celrep.2019.10.107 |
| Citation | Bornes L, et al. (2019) Fsp1-Mediated Lineage Tracing Fails to Detect the Majority of Disseminating Cells Undergoing EMT. Cell Rep 29(9):2565-2569.e3 |
| abstractText | Epithelial-to-mesenchymal transition (EMT) has long been thought to be crucial for metastasis. Recently a study challenged this idea by demonstrating that metastases were seeded by tumor cells that were not marked by an EMT lineage-tracing reporter on the basis of the expression of the mesenchymal marker fsp1. However, the results of this study and their interpretation are under debate. Here, we combine the lineage-tracing reporter with our real-time EMT-state reporter and show that the fsp1-based EMT lineage-tracing reporter does not mark all disseminating mesenchymal cells with metastatic potential. Our findings demonstrate that fsp1-mediated lineage tracing does not allow any conclusions about the requirement of EMT for metastasis. Instead our data are fully consistent with previous reports that EMT is not a binary phenomenon but rather a spectrum of cellular states. |
