| First Author | Pouillon V | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 11 | Pages | 1136-43 |
| PubMed ID | 14517551 | Mgi Jnum | J:86257 |
| Mgi Id | MGI:2679165 | Doi | 10.1038/ni980 |
| Citation | Pouillon V, et al. (2003) Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development. Nat Immunol 4(11):1136-43 |
| abstractText | Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) is phosphorylated by Ins(1,4,5)P(3) 3-kinase, generating inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P(4)). The physiological function of Ins(1,3,4,5)P(4) is still unclear, but it has been reported to be a potential modulator of calcium mobilization. Disruption of the gene encoding the ubiquitously expressed Ins(1,4,5)P(3) 3-kinase isoform B (Itpkb) in mice caused a severe T cell deficiency due to major alterations in thymocyte responsiveness and selection. However, we were unable to detect substantial defects in Ins(1,4,5)P(3) amounts or calcium mobilization in Itpkb(-/-) thymocytes. These data indicate that Itpkb and Ins(1,3,4,5)P(4) define an essential signaling pathway for T cell precursor responsiveness and development. |
