| First Author | Siggs OM | Year | 2012 |
| Journal | Blood | Volume | 119 |
| Issue | 24 | Pages | 5769-71 |
| PubMed ID | 22550345 | Mgi Jnum | J:187583 |
| Mgi Id | MGI:5437476 | Doi | 10.1182/blood-2012-03-417949 |
| Citation | Siggs OM, et al. (2012) iRhom2 is required for the secretion of mouse TNFalpha. Blood 119(24):5769-71 |
| abstractText | TNFalpha is a powerful inflammatory stimulus, central both to the control of infection, and as an agent of inflammatory disease. The most potent inducers of TNFalpha secretion signal through the Toll-like receptors, and we describe here a chemically-induced mutation that impairs this response in macrophages. A missense mutation was revealed in the gene encoding the inactive rhomboid protease iRhom2, which was not complemented by a null allele of the same gene. Neither the missense nor the null allele affected TLR-induced secretion of IL-6. Moreover, unlike a mutation in TNFalpha, the iRhom2 missense mutation did not cause enhanced susceptibility to colitis induced by dextran sodium sulfate. These results establish a specific role for iRhom2 in the secretion of TNFalpha, and present a new target for the modulation of inflammation. |
