| First Author | Morgan DJ | Year | 1996 |
| Journal | J Immunol | Volume | 157 |
| Issue | 3 | Pages | 978-83 |
| PubMed ID | 8757600 | Mgi Jnum | J:99756 |
| Mgi Id | MGI:3583724 | Doi | 10.4049/jimmunol.157.3.978 |
| Citation | Morgan DJ, et al. (1996) CD8(+) T cell-mediated spontaneous diabetes in neonatal mice. J Immunol 157(3):978-83 |
| abstractText | Transgenic mice that express the influenza virus hemagglutinin (HA) on pancreatic islet beta cells (ins-HA) demonstrate tolerance of HA even after immunization with influenza virus. Surprisingly, when Ins-HA mice were mated with a transgenic mouse expressing a TCR specific for an epitope of HA that is restricted by MHC class I H-2Kd (Clone-4 TCR), the resulting double transgenic (Ins-HA x Clone-4 TCR)F1 neonates developed spontaneous autoimmune diabetes immediately after birth and died within 10 days. This represents a unique situation in which all safeguards within the immune system that normally maintain tolerance of self-antigens in the neonate are insufficient. |
