| First Author | Larkin J 3rd | Year | 2007 |
| Journal | Eur J Immunol | Volume | 37 |
| Issue | 1 | Pages | 139-46 |
| PubMed ID | 17154263 | Mgi Jnum | J:117070 |
| Mgi Id | MGI:3695535 | Doi | 10.1002/eji.200636577 |
| Citation | Larkin J 3rd, et al. (2007) Activation of CD4(+)CD25(+) regulatory T cell suppressor function by analogs of the selecting peptide. Eur J Immunol 37(1):139-46 |
| abstractText | CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells can undergo both thymic selection and peripheral expansion in response to self peptides that are agonists for their T cell receptors (TCR). However, the specificity by which these TCR must recognize peptide:MHC complexes to activate Treg cell function is not known. We show that CD4(+)CD25(+)Foxp3(+) Treg cells can mediate suppression in response to peptides that are only weakly cross-reactive with the self peptide that induced their formation in vivo. Moreover, suppression could be efficiently activated by peptide analogs that were inefficient at inducing CD69 up-regulation, and that also induced little or no proliferation of naive CD4(+)CD25(-)Foxp3(-) T cells expressing the same TCR. These findings provide evidence that self peptide-specific CD4(+)CD25(+)Foxp3(+) Treg cells can exert regulatory function in response to self- and/or pathogen-derived peptides with which they are only weakly cross-reactive. |
