| First Author | Sun Y | Year | 2016 |
| Journal | Neuron | Volume | 92 |
| Issue | 1 | Pages | 160-173 |
| PubMed ID | 27641496 | Mgi Jnum | J:253280 |
| Mgi Id | MGI:6109129 | Doi | 10.1016/j.neuron.2016.08.033 |
| Citation | Sun Y, et al. (2016) Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity. Neuron 92(1):160-173 |
| abstractText | Experience alters cortical networks through neural plasticity mechanisms. During a developmental critical period, the most dramatic consequence of occluding vision through one eye (monocular deprivation) is a rapid loss of excitatory synaptic inputs to parvalbumin-expressing (PV) inhibitory neurons in visual cortex. Subsequent cortical disinhibition by reduced PV cell activity allows for excitatory ocular dominance plasticity. However, the molecular mechanisms underlying critical period synaptic plasticity are unclear. Here we show that brief monocular deprivation during the critical period downregulates neuregulin-1(NRG1)/ErbB4 signaling in PV neurons, causing retraction of excitatory inputs to PV neurons. Exogenous NRG1 rapidly restores excitatory inputs onto deprived PV cells through downstream PKC-dependent activation and AMPA receptor exocytosis, thus enhancing PV neuronal inhibition to excitatory neurons. NRG1 treatment prevents the loss of deprived eye visual cortical responsiveness in vivo. Our findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 in regulating the initiation of critical period visual cortical plasticity. |
