| Primary Identifier | MGI:2681319 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Camkk2 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 5 was removed via cre mediated recombination of a single loxP site in intron 4 and the 3' loxP site of a floxed neo cassette in intron 5. The deletion of exon 5 results in the removal of sequence encoding part of the catalytic domain common to all CaM kinase kinase beta isoforms and putatively generates a frameshift mutation that leads to a premature stop codon. Protein was undetected in the forebrain and cerebellum of homozygous mutant mice by homologous recombination. |
