Primary Identifier | MGI:2681980 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Prnp |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The majority of the endogenous mouse gene was replaced with mutant human PRNP sequence. The human sequence contained a nonsense mutation at codon 145. 3' mouse sequence remained downstream of the inserted human sequence. |